Crisis of the middle ages?

This crossword clue is for the definition: Crisis of the middle ages?.
it’s A 26 letters crossword puzzle definition.
Next time, when searching for online help with your puzzle, try using the search term “Crisis of the middle ages? crossword” or “Crisis of the middle ages? crossword clue”. The possible answerss for Crisis of the middle ages? are listed below.

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Possible Answers: SAG.

Last seen on: LA Times Crossword 19 Nov 2017, Sunday

Random information on the term “SAG”:

4ZWJ

6295

20215

ENSG00000281857ENSG00000130561

ENSMUSG00000056055

P10523

P20443

NM_000541

NM_009118

NP_000532

NP_033144


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S-arrestin is a protein that in humans is encoded by the SAG gene.

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.

SAG on Wikipedia