Deep sleep

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Possible Answers: COMA.

Last seen on: LA Times Crossword 10 Jul 2018, Tuesday

Random information on the term “Deep sleep”:

Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle ofrecipient rabbits induces spindle and delta EEG activity and reduced motor activities.[1]

Its aminoacid sequence is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. However, the gene is unknown[citation needed], raising serious questions regarding the actual existence of this peptide in nature.

Delta sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory.[2]

Delta-sleep-inducing peptide (DSIP)-like material has been found in human breast milk.[3]

DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C[4]

Deep sleep on Wikipedia


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Random information on the term “COMA”:

The coma is the nebulous envelope around the nucleus of a comet, formed when the comet passes close to the Sun on its highly elliptical orbit; as the comet warms, parts of it sublime. This gives a comet a “fuzzy” appearance when viewed in telescopes and distinguishes it from stars. The word coma comes from the Greek “kome” (κόμη), which means “hair” and is the origin of the word comet itself.

The coma is generally made of ice and comet dust. Water dominates up to 90% of the volatiles that outflow from the nucleus when the comet is within 3-4 AU of the Sun. The H2O parent molecule is destroyed primarily through photodissociation and to a much smaller extent photoionization. The solar wind plays a minor role in the destruction of water compared to photochemistry. Larger dust particles are left along the comet’s orbital path while smaller particles are pushed away from the Sun into the comet’s tail by light pressure.

On 11 August 2014, astronomers released studies, using the Atacama Large Millimeter/Submillimeter Array (ALMA) for the first time, that detailed the distribution of HCN, HNC, H2CO, and dust inside the comae of comets C/2012 F6 (Lemmon) and C/2012 S1 (ISON). On 2 June 2015, NASA reported that the ALICE spectrograph on the Rosetta space probe studying comet 67P/Churyumov–Gerasimenko determined that electrons (within 1 km (0.62 mi) above the comet nucleus) produced from photoionization of water molecules by solar radiation, and not photons from the Sun as thought earlier, are responsible for the degradation of water and carbon dioxide molecules released from the comet nucleus into its coma.

COMA on Wikipedia