Formal addressees

This crossword clue is for the definition: Formal addressees.
it’s A 17 letters crossword puzzle definition.
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Possible Answers: SIRS.

Last seen on: LA Times Crossword 4 Nov 2017, Saturday

Random information on the term “SIRS”:

Systemic inflammatory response syndrome (SIRS) is an inflammatory state affecting the whole body. It is the body’s response to an infectious or noninfectious insult. Although the definition of SIRS refers to it as an “inflammatory” response, it actually has pro- and anti-inflammatory components.


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The concept of SIRS was first conceived of and presented by Dr. William R. Nelson, of the Department of Surgery of the University of Toronto at the Nordic Micro Circulation meeting in 1983. The presentation followed a decade of research with colleagues including; Dr. J. Vaage of the University of Oslo, Norway, Dr. D. Bigger, the Hospital for Sick Children, Toronto, Dr. D. Sepro of Boston University, and Dr. H. Movat of the Department of Pathology at the University of Toronto. The laboratory experience was borne out in the clinical setting with Canada’s first trauma unit for which Nelson was a co-founder. This allowed in the mid 1980s, the concepts of SIRS to be taught by Dr. Miles Johnson of the university of Toronto, Department of Pathology at the undergraduate dental school, as well as to residents in the Department of Surgery of the University of Toronto who rotated through the Regional Trauma Unit at Sunnybrook Medical Center. SIRS was more broadly adopted in 1991 at the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference with the goal of aiding in the early detection of sepsis. In 2016 SIRS was completely eliminated from the definition of sepsis.

SIRS on Wikipedia