Give a free pass

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it’s A 16 letters crossword puzzle definition.
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Possible Answers: COMP.

Last seen on: LA Times Crossword 28 May 2018, Monday

Random information on the term “COMP”:

3FBY

1311

12845

ENSG00000105664

ENSMUSG00000031849

P49747

Q9R0G6

NM_000095

NM_016685

NP_000086

NP_057894


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Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. In humans it is encoded by the COMP gene.

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

COMP is a marker of cartilage turnover. It is present in high quantities in fibrotic scars and systemic sclerosis, and it appears to have a role in vascular wall remodeling.

COMP on Wikipedia