This crossword clue is for the definition: “Jeepers”.
it’s A 21 letters crossword puzzle definition.
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Possible Answers: EGAD.

Last seen on: LA Times Crossword 3 Jul 19, Wednesday

Random information on the term ““Jeepers””:

E (named e /iː/, plural ees) is the fifth letter and the second vowel in the modern English alphabet and the ISO basic Latin alphabet. It is the most commonly used letter in many languages, including Czech, Danish, Dutch, English, French, German, Hungarian, Latin, Latvian, Norwegian, Spanish, and Swedish.

The Latin letter ‘E’ differs little from its source, the Greek letter epsilon, ‘Ε’. This in turn comes from the Semitic letter hê, which has been suggested to have started as a praying or calling human figure (hillul ‘jubilation’), and was probably based on a similar Egyptian hieroglyph that indicated a different pronunciation. In Semitic, the letter represented /h/ (and /e/ in foreign words); in Greek, hê became the letter epsilon, used to represent /e/. The various forms of the Old Italic script and the Latin alphabet followed this usage.

Although Middle English spelling used ⟨e⟩ to represent long and short /e/, the Great Vowel Shift changed long /eː/ (as in ‘me’ or ‘bee’) to /iː/ while short /ɛ/ (as in ‘met’ or ‘bed’) remained a mid vowel. In other cases, the letter is silent, generally at the end of words.

“Jeepers” on Wikipedia

Random information on the term “EGAD”:

Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to GABA and CO2. GAD uses PLP as a cofactor. The reaction proceeds as follows:

In mammals, GAD exists in two isoforms with molecular weights of 67 and 65 kDa (GAD67 and GAD65), which are encoded by two different genes on different chromosomes (GAD1 and GAD2 genes, chromosomes 4 and 10 respectively). GAD67 and GAD65 are expressed in the brain where GABA is used as a neurotransmitter, and they are also expressed in the insulin-producing β-cells of the pancreas, in varying ratios depending upon the species. Together, these two enzymes maintain the major physiological supply of GABA in mammals, though it may also be synthesized from putrescine in the enteric nervous system, brain, and elsewhere by the actions of diamine oxidase and aldehyde dehydrogenase.

Several truncated transcripts and polypeptides of GAD67 are detectable in the developing brain, however their function, if any, is unknown.

EGAD on Wikipedia