Op. __

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Possible Answers: CIT.

Last seen on: LA Times Crossword 18 Nov 2017, Saturday

Random information on the term “Op. __”:

Optimus Prime, known in Japan as Convoy (コンボイ, Konboi), is a fictional character from the Transformers franchise. He is the leader of the Autobots, a fictional group of sentient robots that can transform into other forms (e.g: cars and other objects) He is the most iconic of the Transformers, being frequently featured in popular culture.

Optimus Prime (formerly Orion Pax) is constantly, if not always depicted as having strong moral character, excellent leadership, and sound decision-making skills, and possesses brilliant military tactics, powerful martial arts, and advanced extra-terrestrial weaponry. Optimus Prime has a strong sense of honor and justice, being dedicated to building peaceful and mutually beneficial co-existence with humans, the protection of life and liberty of all sentient species. As the current Matrix of Leadership bearer, Optimus Prime is the de facto leader of the Autobots, a faction of a transforming species of synthetic intelligence from the planet Cybertron. The Autobots are constantly waging civil war against a rival faction of transforming robots called Decepticons. According to Bob Budiansky, co-writer of the Transformers series, Dennis O’Neil was responsible for his name.

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Op. __ on Wikipedia

Random information on the term “CIT”:

RTI(-4229)-55, also called RTI-55 or iometopane, is a phenyltropane-based psychostimulant used in scientific research and in some medical applications. This drug was first cited in 1991. RTI-55 is a non-selective dopamine reuptake inhibitor derived from methylecgonidine. However, more selective analogs are derived by conversion to “pyrrolidinoamido” RTI-229, for instance. Due to the large bulbous nature of the weakly electron withdrawing iodo halogen atom, RTI-55 is the most strongly serotonergic of the simple para-substituted troparil based analogs. In rodents RTI-55 actually caused death at a dosage of 100 mg/kg, whereas RTI-51 and RTI-31 did not. Another notable observation is the strong propensity of RTI-55 to cause locomotor activity enhancements, although in an earlier study, RTI-51 was actually even stronger than RTI-55 in shifting baseline LMA. This observation serves to highlight the disparities that can arise between studies.

RTI-55 is one of the most potent phenyltropane stimulants commercially available, which limits its use in humans, as it might have significant abuse potential if used outside a strictly controlled medical setting. However, it is definitely worthy of mentioning that increasing the size of the halogen atom attached to troparil serves to reduce the number of lever responses in a session when these analogs were compared in a study. Although RTI-55 wasn’t specifically examined in this study the number of lever responses in a given session was of the order cocaine > WIN35428 > RTI-31 > RTI-51.

CIT on Wikipedia