Pill or a reason to take a pill

This crossword clue is for the definition: Pill or a reason to take a pill.
it’s A 33 letters crossword puzzle definition.
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Possible Answers: PAIN.

Last seen on: NY Times Crossword 15 Sep 20, Tuesday

Random information on the term “PAIN”:

Pain or Oh Pain, Little Pain, Pain (Spanish: ¡Ay, pena, penita, pena!) is a 1953 Mexican-Spanish musical comedy film directed by Miguel Morayta and starring Lola Flores, Luis Aguilar and Antonio Badú.

PAIN on Wikipedia