ravel pillow spot

This crossword clue is for the definition: ravel pillow spot.
it’s A 17 letters crossword puzzle definition.
Next time, when searching for online help with your puzzle, try using the search term “ravel pillow spot crossword” or “ravel pillow spot crossword clue”. The possible answerss for ravel pillow spot are listed below.

Did you find what you needed?
We hope you did!.

Possible Answers: NAPE.

Last seen on: LA Times Crossword 14 Apr 19, Sunday

Random information on the term “NAPE”:

N-Acylphosphatidylethanolamines (NAPEs) are hormones released by the small intestine into the bloodstream when it processes fat. NAPEs travel to the hypothalamus in the brain and suppress appetite. This mechanism could be relevant for treating obesity.[1]

N-Acylphosphatidylethanolamines are also an important intermediaries in the biosynthesis of endocannabinoids.


New Crossword clues and help App now available in the App Store and Google Play Store!
Crossword clues app Android Crossword clues app iphone iOs

NAPEs are formed from phosphatidylethanolamines, a group of cell membrane phospholipids characteristic of nervous tissue. After being cleaved by phospholipases, NAPEs can be transformed into N-acylethanolamines, including the endocannabinoid anandamide.[2][3] While NAPE-PLD is the enzyme responsible for catalyzing said release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE), this specific subtype of phospholipase D is not responsible for the formation of the anandamide.[4]

The crystal structure of human N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) reveals how this membrane enzyme generates anandamide and other bioactive lipid amides from membrane NAPEs.[5] A hydrophobic cavity in NAPE-PLD provides an entryway for the substrate NAPE into the active site, where a binuclear zinc center orchestrates its hydrolysis. Unexpectedly, the structure unveils bile acids bind the membrane enzyme, enhancing dimer assembly and enabling catalysis. These findings suggest NAPE-PLD might orchestrate a direct crosstalk between bile acids and lipid amide signals.[5]

NAPE on Wikipedia