Runs out of air? Oh dear!

This crossword clue is for the definition: Runs out of air? Oh dear!.
it’s A 25 letters crossword puzzle definition.
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Possible Answers: DIARRHOEA.

Last seen on: The Guardian – Cryptic Crossword No 28,266 – Oct 16 2020

Random information on the term “DIARRHOEA”:

Ulcerative colitis (UC) is a long-term condition that results in inflammation and ulcers of the colon and rectum. The primary symptoms of active disease are abdominal pain and diarrhea mixed with blood. Weight loss, fever, and anemia may also occur. Often, symptoms come on slowly and can range from mild to severe. Symptoms typically occur intermittently with periods of no symptoms between flares. Complications may include abnormal dilation of the colon (megacolon), inflammation of the eye, joints, or liver, and colon cancer.

The cause of UC is unknown. Theories involve immune system dysfunction, genetics, changes in the normal gut bacteria, and environmental factors. Rates tend to be higher in the developed world with some proposing this to be the result of less exposure to intestinal infections, or to a Western diet and lifestyle. The removal of the appendix at an early age may be protective. Diagnosis is typically by colonoscopy with tissue biopsies. It is a kind of inflammatory bowel disease (IBD) along with Crohn’s disease and microscopic colitis.

DIARRHOEA on Wikipedia