Stress, they say

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Possible Answers: AGER.

Last seen on: LA Times Crossword 10 Jun 2018, Sunday

Random information on the term “AGER”:

Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars. They can be a factor in aging and in the development or worsening of many degenerative diseases, such as diabetes, atherosclerosis, chronic kidney disease, and Alzheimer’s disease.


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Animal-derived foods that are high in fat and protein are generally AGE-rich and are prone to further AGE formation during cooking.

AGEs affect nearly every type of cell and molecule in the body and are thought to be one factor in aging and some age-related chronic diseases. They are also believed to play a causative role in the vascular complications of diabetes mellitus.

Under certain pathologic conditions, such as oxidative stress due to hyperglycemia in patients with diabetes, and hyperlipidemia,[citation needed] AGE formation can be increased beyond normal levels. AGEs are now known to play a role as proinflammatory mediators in gestational diabetes as well.

AGER on Wikipedia