Sucker

This crossword clue is for the definition: Sucker.
it’s A 6 letters crossword puzzle definition.
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Possible Answers: SAP.

Last seen on: LA Times Crossword 10 Nov 2017, Friday

Random information on the term “Sucker”:

A lollipop is a type of confectionery consisting of a sweetmeat of hard candy or water-ice mounted on a stick and intended for sucking or licking. Different informal terms are used in different places, including lolly, sucker, sticky-pop, etc.[citation needed] Lollipops are available in many flavors and shapes.

Lollipops are available in a number of colors and flavors, particularly fruit flavors. With numerous companies producing lollipops, the candy now comes in dozens of flavors and many different shapes. They range from small ones which can be bought by the hundred and are often given away for free at banks, barbershops, and other locations, to very large ones made out of candy canes twisted into a circle.

Most lollipops are eaten at room temperature, but “ice lollipops” or “ice lollies” are frozen water-based lollipops. Similar confections on a stick made of ice cream, often with a flavored coating, are usually not called by this name.

Some lollipops contain fillings, such as bubble gum or soft candy. Some novelty lollipops have more unusual items, such as mealworm larvae, embedded in the candy. Other novelty lollipops have non-edible centers, such a flashing light, embedded within the candy; there is also a trend[where?] of lollipops with sticks attached to a motorized device that makes the entire lollipop spin around in one’s mouth.


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Sucker on Wikipedia

Random information on the term “SAP”:

4AYU, 1GYK, 1LGN, 1SAC, 2A3W, 2A3X, 2A3Y, 2W08, 3D5O, 3KQR, 4AVS, 4AVT, 4AVV

325

20219

ENSG00000132703

ENSMUSG00000026542

P02743

P12246

NM_001639

NM_011318

NP_001630

NP_035448

The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called “amyloid”. APCS is its human gene.

AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal globular proteins and peptides into insoluble fibres which disrupt tissue architecture and are associated with cell death. AP is thought to decorate and stabilise aggregates by preventing proteolytic cleavage and hence inhibiting fibril removal via the normal protein scavenging mechanisms. This association is utilised in the routine clinical diagnostic technique of SAP scintigraphy whereby radio-labelled protein is injected into patients to locate areas of amyloid deposition. The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of a compound called CPHPC (R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxohexanoyl] pyrrolidine-2-carboxylic acid), a small molecule able to strip AP from deposits by reducing levels of circulating SAP.

SAP on Wikipedia