Word with pack or pick

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it’s A 22 letters crossword puzzle definition.
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Possible Answers: ICE.

Last seen on: LA Times Crossword 27 May 2018, Sunday

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Random information on the term “ICE”:

ICE in the context of chemotherapy is an acronym for one of the chemotherapy regimens, used in salvage treatment of relapsed or refractory non-Hodgkin’s lymphoma and Hodgkin lymphoma.

In case of CD20-positive B cell lymphoid malignancies the ICE regimen is often combined today with rituximab. This regimen is then called ICE-R or R-ICE or RICE.

[R]-ICE regimen consists of:

Cycles are repeated every 14 days for 3 cycles, then high-dose chemotherapy with autologous stem-cell transplantation follows (if the patient is considered eligible for HDCT and ASCT).

ICE on Wikipedia